The dynamic bending and twisting of actin is critical for many cellular processes. There exist many efforts to model actin using spatial simulation methods that represent different spatiotemporal scales. However, each of these simulations methods may have limitations due to implementation and assumptions necessary for the simulated spatial scale.

We propose to run simulations of single actin filament compression at monomer- and fiber-scales using the ReaDDy and Cytosim simulation engines, respectively, under different compression velocities. By comparing the results of these simulations, we can identify regimes in which simulator predictions are (or are not) consistent and guiding principles for future multi-scale, compositional model development.